Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Located in cytosol and nucleoplasm. Part of ubiquitin ligase complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ARMC8. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ARMC8 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ARMC8, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:138,009,757–138,010,666 | 177.2 kb | Distal (>10kb) Multiome | 133 | |
| chr3:138,019,195–138,020,432 | 167.4 kb | Distal (>10kb) Multiome | 203 | |
| chr3:138,115,002–138,116,017 | 71.9 kb | Distal (>10kb) Multiome | 555 | |
| chr3:138,118,769–138,119,220 | 68.3 kb | Distal (>10kb) Multiome | 232 | |
| chr3:138,174,233–138,175,030 | 12.6 kb | Distal (>10kb) Multiome | 817 | |
| chr3:138,186,777–138,188,242 | at TSS | At TSS Multiome | 867 | |
| chr3:138,329,184–138,330,233 | 142.5 kb | Distal (>10kb) Multiome | 580 | |
| chr3:138,347,955–138,349,547 | 161.1 kb | Distal (>10kb) Multiome | 615 | |
| chr3:138,417,585–138,418,044 | 230.4 kb | Distal (>10kb) Multiome | 243 | |
| chr3:138,434,084–138,435,298 | 247.2 kb | Distal (>10kb) Multiome | 811 |
Genomic view of the ARMC8 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.