Involved in sperm axoneme assembly. Implicated in spermatogenic failure 38. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ARMC2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ARMC2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ARMC2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:108,557,184–108,561,557 | 287.6 kb | Distal (>10kb) Multiome HiCAR | 1119 | |
| chr6:108,561,776–108,563,199 | 285.6 kb | Distal (>10kb) Multiome HiCAR | 782 | |
| chr6:108,781,208–108,782,610 | 66.9 kb | Distal (>10kb) Multiome | 561 | |
| chr6:108,838,106–108,838,816 | 10.0 kb | Distal (>10kb) Multiome | 212 | |
| chr6:108,847,848–108,848,955 | 21 bp | At TSS Multiome | 734 | |
| chr6:109,008,977–109,009,970 | 161.1 kb | Distal (>10kb) Multiome | 785 | |
| chr6:109,094,199–109,095,904 | 246.5 kb | Distal (>10kb) Multiome | 1009 |
Genomic view of the ARMC2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.