The protein encoded by this gene belongs to the ARF family of GTP-binding proteins. With its distinctive nuclear/nucleolar localization and interaction with HP1alpha, the protein is developmentally regulated and may play a role(s) in nuclear dynamics and/or signaling cascades during embryonic development. Alternative splicing results in multiple transcript variants encoding different isoforms. This gene has multiple pseudogenes. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for ARL5A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ARL5A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ARL5A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:151,827,563–151,829,025 | 23 bp | At TSS Multiome | 918 | |
| chr2:151,947,105–151,947,762 | 119.0 kb | Distal (>10kb) Multiome | 177 | |
| chr2:152,042,296–152,043,510 | 214.5 kb | Distal (>10kb) Multiome | 242 | |
| chr2:152,055,231–152,056,165 | 227.2 kb | Distal (>10kb) Multiome | 199 | |
| chr2:152,097,676–152,099,753 | 270.5 kb | Distal (>10kb) Multiome | 496 |
Genomic view of the ARL5A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.