ADP-ribosylation factor-like 4A is a member of the ADP-ribosylation factor family of GTP-binding proteins. ARL4A is similar to ARL4C and ARL4D and each has a nuclear localization signal and an unusually high guaninine nucleotide exchange rate. ARL4A is located in both the nuclear and extranuclear cell compartments. Multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for ARL4A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ARL4A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ARL4A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:12,403,223–12,404,775 | 283.8 kb | Distal (>10kb) Multiome | 590 | |
| chr7:12,423,909–12,424,530 | 263.3 kb | Distal (>10kb) Multiome | 203 | |
| chr7:12,570,159–12,571,611 | 116.7 kb | Distal (>10kb) Multiome | 430 | |
| chr7:12,681,715–12,682,210 | 4.6 kb | Proximal (<10kb) | 15 | |
| chr7:12,683,777–12,683,944 | 2.9 kb | Proximal (<10kb) | 57 | |
| chr7:12,684,789–12,684,943 | 1.9 kb | Proximal (<10kb) | 17 | |
| chr7:12,685,524–12,686,068 | 786 bp | At TSS | 136 | |
| chr7:12,686,188–12,688,064 | 97 bp | At TSS Multiome | 1066 | |
| chr7:12,715,491–12,716,600 | 28.3 kb | Distal (>10kb) Multiome | 633 |
Genomic view of the ARL4A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.