The protein encoded by this gene is an effector protein. It interacts with ADP-ribosylation factor-like 14 [ARL14, also known as ADP-ribosylation factor 7 (ARF7)], beta-actin (ACTB) and actin-based motor protein myosin 1E (MYO1E). ARL14 is a small GTPase; it controls the export of major histocompatibility class II molecules by connecting to the actin network via this effector protein. [provided by RefSeq, Sep 2014]
Transcription factors with Perturb-seq knockdown data for ARL14EP. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ARL14EP upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ARL14EP, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:30,025,238–30,026,334 | 297.4 kb | Distal (>10kb) Multiome | 161 | |
| chr11:30,312,391–30,313,321 | 9.8 kb | Proximal (<10kb) | 97 | |
| chr11:30,322,721–30,323,893 | 8 bp | At TSS Multiome | 976 | |
| chr11:30,406,743–30,407,889 | 84.3 kb | Distal (>10kb) Multiome | 242 | |
| chr11:30,430,813–30,431,690 | 108.2 kb | Distal (>10kb) Multiome | 212 | |
| chr11:30,583,719–30,587,093 | 263.2 kb | Distal (>10kb) Multiome | 529 |
Genomic view of the ARL14EP locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.