The protein encoded by this gene belongs to the ARL (ADP-ribosylation factor-like) family of proteins, which are structurally related to ADP-ribosylation factors (ARFs). ARFs, described as activators of cholera toxin (CT) ADP-ribosyltransferase activity, regulate intracellular vesicular membrane trafficking, and stimulate a phospholipase D (PLD) isoform. Although, ARL proteins were initially thought not to activate CT or PLD, later work showed that they are weak stimulators of PLD and CT in a phospholipid dependent manner. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]
Transcription factors with Perturb-seq knockdown data for ARL1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ARL1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ARL1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:101,221,083–101,221,871 | 186.3 kb | Distal (>10kb) Multiome | 165 | |
| chr12:101,279,367–101,280,709 | 127.7 kb | Distal (>10kb) Multiome | 660 | |
| chr12:101,406,958–101,408,760 | 121 bp | At TSS Multiome | 896 | |
| chr12:101,414,633–101,414,829 | 6.9 kb | Proximal (<10kb) | 103 | |
| chr12:101,696,663–101,698,677 | 289.9 kb | Distal (>10kb) Multiome | 939 | |
| chr12:101,830,071–101,831,573 | 423.2 kb | Distal (>10kb) Multiome HiCAR | 637 |
Genomic view of the ARL1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.