ARID5A

AT-rich interaction domain 5A | MRF-1, RP11-363D14

Members of the ARID protein family, including ARID5A, have diverse functions but all appear to play important roles in development, tissue-specific gene expression, and regulation of cell growth (Patsialou et al., 2005 [PubMed 15640446]).[supplied by OMIM, Mar 2008]

Biological processes 32 terms

DNA binding (GO:0003677)DNA binding (GO:0003677)RNA stem-loop binding (GO:0035613)cellular response to estrogen stimulus (GO:0071391)cellular response to lipopolysaccharide (GO:0071222)chromatin binding (GO:0003682)identical protein binding (GO:0042802)mRNA 3'-UTR AU-rich region binding (GO:0035925)negative regulation of DNA-templated transcription (GO:0045892)negative regulation of transcription by RNA polymerase II (GO:0000122)nuclear androgen receptor binding (GO:0050681)nuclear estrogen receptor binding (GO:0030331)nuclear retinoid X receptor binding (GO:0046965)nuclear thyroid hormone receptor binding (GO:0046966)nucleolus (GO:0005730)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)positive regulation of 3'-UTR-mediated mRNA stabilization (GO:1905870)positive regulation of T-helper 1 cell cytokine production (GO:2000556)positive regulation of T-helper 17 type immune response (GO:2000318)positive regulation of interleukin-17 production (GO:0032740)positive regulation of interleukin-6 production (GO:0032755)positive regulation of tumor necrosis factor production (GO:0032760)positive regulation of type II interferon production (GO:0032729)protein binding (GO:0005515)regulation of transcription by RNA polymerase II (GO:0006357)sequence-specific DNA binding (GO:0043565)transcription cis-regulatory region binding (GO:0000976)transcription corepressor activity (GO:0003714)transcription factor binding (GO:0008134)transcription regulator complex (GO:0005667)

Expression (TPM)

TFs regulating ARID5A 0 TFs

Transcription factors with Perturb-seq knockdown data for ARID5A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ARID5A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to ARID5A

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ARID5A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr2:96,265,014–96,266,655	270.6 kb	Distal (>10kb) Multiome	992
chr2:96,305,302–96,305,947	231.1 kb	Distal (>10kb) Multiome	918
chr2:96,321,245–96,322,149	214.9 kb	Distal (>10kb) Multiome	640
chr2:96,325,023–96,325,881	211.4 kb	Distal (>10kb) Multiome	443
chr2:96,335,437–96,336,197	200.8 kb	Distal (>10kb) Multiome	847
chr2:96,507,900–96,508,563	28.6 kb	Distal (>10kb) Multiome	466
chr2:96,509,253–96,509,998	27.1 kb	Distal (>10kb) Multiome	525
chr2:96,527,233–96,527,841	8.9 kb	Proximal (<10kb)	215
chr2:96,531,989–96,532,491	4.4 kb	Proximal (<10kb) Multiome	500
chr2:96,536,180–96,538,128	76 bp	At TSS Multiome	684
chr2:96,538,413–96,539,012	2.0 kb	Proximal (<10kb) Multiome	371
chr2:96,539,488–96,539,838	2.7 kb	Proximal (<10kb)	20
chr2:96,554,285–96,554,861	17.9 kb	Distal (>10kb) Multiome	435
chr2:96,637,810–96,638,901	101.5 kb	Distal (>10kb) Multiome	1144
chr2:96,739,549–96,740,363	203.4 kb	Distal (>10kb) Multiome	708
chr2:96,760,354–96,761,531	224.1 kb	Distal (>10kb) Multiome	776
chr2:96,815,434–96,817,859	279.5 kb	Distal (>10kb) Multiome	926

Genome Browser

Genomic view of the ARID5A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.