Enables guanyl-nucleotide exchange factor activity. Acts upstream of or within actin cytoskeleton organization. Predicted to be located in cytosol. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ARHGEF17. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ARHGEF17 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ARHGEF17, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:73,141,056–73,143,237 | 165.8 kb | Distal (>10kb) Multiome | 1038 | |
| chr11:73,217,837–73,218,810 | 89.9 kb | Distal (>10kb) Multiome | 603 | |
| chr11:73,242,414–73,243,061 | 65.6 kb | Distal (>10kb) Multiome | 448 | |
| chr11:73,307,026–73,309,843 | 643 bp | At TSS Multiome | 963 | |
| chr11:73,314,550–73,314,911 | 6.3 kb | Proximal (<10kb) | 355 | |
| chr11:73,342,698–73,343,488 | 34.7 kb | Distal (>10kb) Multiome | 124 | |
| chr11:73,361,895–73,362,672 | 54.0 kb | Distal (>10kb) Multiome | 245 | |
| chr11:73,375,760–73,377,389 | 68.0 kb | Distal (>10kb) Multiome | 817 | |
| chr11:73,597,688–73,598,911 | 290.0 kb | Distal (>10kb) Multiome | 887 |
Genomic view of the ARHGEF17 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.