This gene encodes a Rho guanine nucleotide exchange factor (GEF). Rho GEFs regulate the activity of small Rho GTPases by stimulating the exchange of guanine diphosphate (GDP) for guanine triphosphate (GTP) and may play a role in neural morphogenesis. Mutations in this gene are associated with slowed nerve conduction velocity (SNCV). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
Transcription factors with Perturb-seq knockdown data for ARHGEF10. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ARHGEF10 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ARHGEF10, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:1,657,940–1,658,466 | 165.8 kb | Distal (>10kb) Multiome | 132 | |
| chr8:1,700,997–1,701,729 | 122.6 kb | Distal (>10kb) Multiome | 300 | |
| chr8:1,763,611–1,765,449 | 60.4 kb | Distal (>10kb) Multiome | 769 | |
| chr8:1,801,852–1,803,309 | 21.2 kb | Distal (>10kb) Multiome | 182 | |
| chr8:1,816,753–1,817,762 | 6.9 kb | Proximal (<10kb) Multiome | 113 | |
| chr8:1,823,171–1,824,563 | 251 bp | At TSS Multiome | 514 | |
| chr8:1,827,869–1,828,294 | 3.9 kb | Proximal (<10kb) | 30 | |
| chr8:1,973,408–1,974,934 | 149.9 kb | Distal (>10kb) Multiome | 298 | |
| chr8:2,000,722–2,003,182 | 177.8 kb | Distal (>10kb) Multiome | 414 | |
| chr8:2,063,936–2,064,980 | 240.6 kb | Distal (>10kb) Multiome | 138 |
Genomic view of the ARHGEF10 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.