Predicted to enable GTPase activator activity. Predicted to be involved in negative regulation of small GTPase mediated signal transduction. Located in cytosol and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ARHGAP45. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ARHGAP45 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ARHGAP45, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:796,668–798,362 | 269.9 kb | Distal (>10kb) Multiome | 956 | |
| chr19:821,294–822,728 | 245.0 kb | Distal (>10kb) Multiome | 254 | |
| chr19:861,664–863,223 | 204.9 kb | Distal (>10kb) Multiome | 530 | |
| chr19:892,703–893,746 | 174.0 kb | Distal (>10kb) Multiome | 715 | |
| chr19:917,038–918,169 | 149.4 kb | Distal (>10kb) Multiome | 711 | |
| chr19:924,743–926,242 | 141.5 kb | Distal (>10kb) Multiome | 796 | |
| chr19:982,565–983,215 | 84.3 kb | Distal (>10kb) Multiome | 590 | |
| chr19:984,046–985,154 | 82.7 kb | Distal (>10kb) Multiome | 829 | |
| chr19:1,020,611–1,022,069 | 45.7 kb | Distal (>10kb) Multiome | 1017 | |
| chr19:1,026,155–1,026,856 | 40.7 kb | Distal (>10kb) Multiome | 598 | |
| chr19:1,027,770–1,028,926 | 38.7 kb | Distal (>10kb) Multiome | 584 | |
| chr19:1,039,648–1,040,400 | 27.2 kb | Distal (>10kb) Multiome | 684 | |
| chr19:1,040,481–1,041,402 | 26.0 kb | Distal (>10kb) Multiome | 556 | |
| chr19:1,044,758–1,045,598 | 21.8 kb | Distal (>10kb) Multiome | 402 | |
| chr19:1,061,840–1,062,923 | 4.5 kb | Proximal (<10kb) Multiome | 204 | |
| chr19:1,063,045–1,065,722 | 2.4 kb | Proximal (<10kb) Multiome | 681 | |
| chr19:1,066,682–1,067,587 | at TSS | At TSS | 489 | |
| chr19:1,071,107–1,071,721 | 4.0 kb | Proximal (<10kb) Multiome | 178 | |
| chr19:1,081,317–1,083,172 | 15.2 kb | Distal (>10kb) Multiome | 484 | |
| chr19:1,094,985–1,095,654 | 28.3 kb | Distal (>10kb) Multiome | 671 | |
| chr19:1,103,487–1,105,654 | 36.8 kb | Distal (>10kb) Multiome | 849 | |
| chr19:1,112,029–1,112,884 | 45.1 kb | Distal (>10kb) Multiome | 294 | |
| chr19:1,113,014–1,114,139 | 46.4 kb | Distal (>10kb) Multiome | 690 | |
| chr19:1,122,934–1,123,720 | 56.1 kb | Distal (>10kb) Multiome | 231 | |
| chr19:1,173,441–1,174,438 | 107.1 kb | Distal (>10kb) Multiome | 682 | |
| chr19:1,205,175–1,206,374 | 138.4 kb | Distal (>10kb) Multiome HiCAR | 746 | |
| chr19:1,239,513–1,242,539 | 173.2 kb | Distal (>10kb) Multiome | 889 | |
| chr19:1,247,981–1,252,501 | 181.4 kb | Distal (>10kb) Multiome | 1136 | |
| chr19:1,259,185–1,262,955 | 193.8 kb | Distal (>10kb) Multiome | 1070 | |
| chr19:1,265,280–1,270,235 | 202.1 kb | Distal (>10kb) Multiome | 1171 | |
| chr19:1,274,423–1,276,502 | 208.6 kb | Distal (>10kb) Multiome | 967 | |
| chr19:1,285,317–1,286,108 | 218.6 kb | Distal (>10kb) Multiome | 277 | |
| chr19:1,354,303–1,355,411 | 287.7 kb | Distal (>10kb) Multiome | 688 |
Genomic view of the ARHGAP45 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.