This gene encodes a Rho GTPase-activating protein (RhoGAP), and member of the GRAF or BAR-PH family of proteins. Expression of this gene is enriched in vascular smooth muscle cells and the encoded protein inhibits RhoA activity to regulate vascular tone and control blood pressure. A mutation in the first intron of this gene modulates its expression and is associated with reduced blood pressure in human patients with borderline hypertension. [provided by RefSeq, Jul 2017]
Transcription factors with Perturb-seq knockdown data for ARHGAP42. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ARHGAP42 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ARHGAP42, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:100,676,939–100,677,503 | 9.8 kb | Proximal (<10kb) | 134 | |
| chr11:100,681,156–100,681,375 | 5.9 kb | Proximal (<10kb) | 372 | |
| chr11:100,686,543–100,688,108 | 61 bp | At TSS Multiome | 641 | |
| chr11:100,731,157–100,732,205 | 44.4 kb | Distal (>10kb) Multiome | 145 | |
| chr11:100,752,981–100,753,945 | 66.3 kb | Distal (>10kb) Multiome | 211 | |
| chr11:100,827,590–100,828,785 | 141.0 kb | Distal (>10kb) Multiome | 232 | |
| chr11:100,873,747–100,874,954 | 187.1 kb | Distal (>10kb) Multiome | 191 |
Genomic view of the ARHGAP42 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.