RICS is a neuron-associated GTPase-activating protein that may regulate dendritic spine morphology and strength by modulating Rho GTPase (see RHOA; MIM 165390) activity (Okabe et al., 2003 [PubMed 12531901]).[supplied by OMIM, Mar 2008]
Transcription factors with Perturb-seq knockdown data for ARHGAP32. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ARHGAP32 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ARHGAP32, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:129,148,421–129,149,166 | 130.6 kb | Distal (>10kb) Multiome | 141 | |
| chr11:129,278,642–129,280,370 | 251 bp | At TSS Multiome | 573 | |
| chr11:129,282,721–129,282,900 | 3.4 kb | Proximal (<10kb) | 28 | |
| chr11:129,283,033–129,283,452 | 3.7 kb | Proximal (<10kb) | 136 | |
| chr11:129,284,900–129,285,120 | 5.6 kb | Proximal (<10kb) | 112 | |
| chr11:129,315,607–129,316,499 | 36.6 kb | Distal (>10kb) Multiome | 338 | |
| chr11:129,364,022–129,364,659 | 85.0 kb | Distal (>10kb) Multiome | 565 | |
| chr11:129,372,615–129,373,768 | 93.9 kb | Distal (>10kb) Multiome | 200 | |
| chr11:129,375,173–129,376,615 | 96.6 kb | Distal (>10kb) Multiome | 465 |
Genomic view of the ARHGAP32 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.