Predicted to enable GTPase activator activity. Predicted to be involved in negative regulation of stress fiber assembly; regulation of actin filament polymerization; and regulation of small GTPase mediated signal transduction. Located in cell junction and nucleoplasm. Implicated in allergic disease. Biomarker of meningioma. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ARHGAP28. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ARHGAP28 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ARHGAP28, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr18:6,482,378–6,482,977 | 247.0 kb | Distal (>10kb) Multiome | 341 | |
| chr18:6,561,157–6,562,323 | 168.0 kb | Distal (>10kb) Multiome HiCAR | 293 | |
| chr18:6,566,061–6,566,935 | 163.1 kb | Distal (>10kb) Multiome HiCAR | 179 | |
| chr18:6,570,439–6,571,791 | 158.5 kb | Distal (>10kb) Multiome HiCAR | 173 | |
| chr18:6,605,761–6,607,586 | 123.0 kb | Distal (>10kb) Multiome | 180 | |
| chr18:6,728,822–6,730,206 | 36 bp | At TSS Multiome | 645 | |
| chr18:6,752,365–6,752,862 | 23.0 kb | Distal (>10kb) Multiome | 177 |
Genomic view of the ARHGAP28 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.