This gene encodes a member of a large family of proteins that activate Rho-type guanosine triphosphate (GTP) metabolizing enzymes. The encoded protein may pay a role in clathrin-mediated endocytosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2013]
Transcription factors with Perturb-seq knockdown data for ARHGAP27. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ARHGAP27 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ARHGAP27, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:45,131,590–45,133,655 | 293.1 kb | Distal (>10kb) Multiome | 898 | |
| chr17:45,135,189–45,136,052 | 290.1 kb | Distal (>10kb) Multiome | 930 | |
| chr17:45,143,207–45,145,183 | 281.1 kb | Distal (>10kb) Multiome | 308 | |
| chr17:45,147,066–45,150,271 | 278.2 kb | Distal (>10kb) Multiome | 1345 | |
| chr17:45,160,688–45,162,340 | 263.9 kb | Distal (>10kb) Multiome | 1200 | |
| chr17:45,197,493–45,198,189 | 227.7 kb | Distal (>10kb) Multiome | 835 | |
| chr17:45,241,380–45,242,217 | 183.8 kb | Distal (>10kb) Multiome | 131 | |
| chr17:45,246,828–45,248,615 | 177.8 kb | Distal (>10kb) Multiome | 858 | |
| chr17:45,261,690–45,262,406 | 163.5 kb | Distal (>10kb) Multiome | 234 | |
| chr17:45,316,202–45,317,910 | 108.5 kb | Distal (>10kb) Multiome | 857 | |
| chr17:45,371,481–45,372,140 | 53.8 kb | Distal (>10kb) Multiome | 704 | |
| chr17:45,395,009–45,395,645 | 30.2 kb | Distal (>10kb) Multiome | 482 | |
| chr17:45,404,953–45,406,129 | 20.2 kb | Distal (>10kb) Multiome | 244 | |
| chr17:45,425,403–45,426,061 | 182 bp | At TSS Multiome | 506 | |
| chr17:45,427,967–45,428,575 | 2.6 kb | Proximal (<10kb) Multiome | 454 | |
| chr17:45,429,511–45,430,237 | 4.1 kb | Proximal (<10kb) Multiome | 190 | |
| chr17:45,431,253–45,432,633 | 6.1 kb | Proximal (<10kb) Multiome | 435 |
Genomic view of the ARHGAP27 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.