Interaction of a cell with the extracellular matrix triggers integrin cell surface receptors to begin signaling cascades that regulate the organization of the actin-cytoskeleton. One of the proteins involved in these cascades is focal adhesion kinase. The protein encoded by this gene is a GTPase activating protein that binds to focal adhesion kinase and mediates the activity of the GTP binding proteins RhoA and Cdc42. Defects in this gene are a cause of juvenile myelomonocytic leukemia (JMML). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2017]
Transcription factors with Perturb-seq knockdown data for ARHGAP26. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ARHGAP26 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ARHGAP26, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:142,474,915–142,475,538 | 295.1 kb | Distal (>10kb) Multiome | 253 | |
| chr5:142,551,285–142,552,143 | 218.6 kb | Distal (>10kb) Multiome | 331 | |
| chr5:142,713,185–142,713,712 | 56.9 kb | Distal (>10kb) Multiome | 662 | |
| chr5:142,769,681–142,771,504 | 79 bp | At TSS Multiome | 878 | |
| chr5:142,863,871–142,864,947 | 93.7 kb | Distal (>10kb) Multiome HiCAR | 173 | |
| chr5:142,895,964–142,896,857 | 126.0 kb | Distal (>10kb) Multiome | 436 | |
| chr5:143,014,069–143,015,003 | 244.0 kb | Distal (>10kb) Multiome | 215 | |
| chr5:143,036,841–143,037,629 | 266.9 kb | Distal (>10kb) Multiome | 265 |
Genomic view of the ARHGAP26 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.