The RHO (see ARHA; MIM 165390) family of small GTPases are involved in signal transduction through transmembrane receptors, and they are inactive in the GDP-bound form and active in the GTP-bound form. GTPase-activating proteins, such as ARHGAP23, inactivate RHO family proteins by stimulating their hydrolysis of GTP (Katoh and Katoh, 2004 [PubMed 15254754]).[supplied by OMIM, Mar 2008]
Transcription factors with Perturb-seq knockdown data for ARHGAP23. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ARHGAP23 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ARHGAP23, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:36,544,068–36,546,005 | 1883.0 kb | Distal (>10kb) Multiome HiCAR | 968 | |
| chr17:38,351,522–38,352,472 | 76.6 kb | Distal (>10kb) Multiome | 809 | |
| chr17:38,414,746–38,415,878 | 13.5 kb | Distal (>10kb) Multiome | 792 | |
| chr17:38,419,123–38,419,320 | 9.1 kb | Proximal (<10kb) | 77 | |
| chr17:38,423,757–38,423,933 | 4.5 kb | Proximal (<10kb) | 181 | |
| chr17:38,428,075–38,428,868 | at TSS | At TSS | 298 | |
| chr17:38,444,178–38,444,391 | 9.3 kb | Proximal (<10kb) | 319 | |
| chr17:38,453,611–38,454,219 | at TSS | At TSS | 168 | |
| chr17:38,509,961–38,510,926 | 82.1 kb | Distal (>10kb) Multiome | 409 | |
| chr17:38,558,106–38,558,652 | 129.9 kb | Distal (>10kb) Multiome | 631 | |
| chr17:38,559,205–38,559,900 | 131.2 kb | Distal (>10kb) Multiome | 598 | |
| chr17:38,572,553–38,573,232 | 144.5 kb | Distal (>10kb) Multiome | 231 | |
| chr17:38,604,448–38,605,250 | 176.4 kb | Distal (>10kb) Multiome | 375 | |
| chr17:38,605,359–38,606,888 | 178.1 kb | Distal (>10kb) Multiome | 781 | |
| chr17:38,609,172–38,610,061 | 181.2 kb | Distal (>10kb) Multiome | 229 | |
| chr17:38,673,658–38,675,315 | 246.6 kb | Distal (>10kb) Multiome | 847 | |
| chr17:38,701,857–38,703,072 | 273.9 kb | Distal (>10kb) Multiome | 907 | |
| chr17:38,703,568–38,704,668 | 275.5 kb | Distal (>10kb) Multiome | 955 | |
| chr17:38,704,725–38,707,220 | 276.8 kb | Distal (>10kb) Multiome | 784 | |
| chr17:38,718,492–38,719,127 | 290.3 kb | Distal (>10kb) Multiome | 268 | |
| chr17:38,719,228–38,720,635 | 291.8 kb | Distal (>10kb) Multiome | 290 | |
| chr17:38,729,824–38,730,713 | 301.8 kb | Distal (>10kb) Multiome | 794 | |
| chr17:38,747,498–38,750,334 | 321.4 kb | Distal (>10kb) Multiome | 914 | |
| chr17:38,751,747–38,753,201 | 324.2 kb | Distal (>10kb) Multiome | 986 |
Genomic view of the ARHGAP23 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.