This gene encodes a member of a large family of proteins that activate Rho-type guanosine triphosphate (GTP) metabolizing enzymes. The encoded protein contains a SRC homology 3 domain and interacts with Bcl-2-associated protein family members. [provided by RefSeq, Aug 2012]
Transcription factors with Perturb-seq knockdown data for ARHGAP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ARHGAP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ARHGAP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:46,407,311–46,408,466 | 292.7 kb | Distal (>10kb) Multiome | 157 | |
| chr11:46,554,280–46,555,184 | 145.9 kb | Distal (>10kb) Multiome | 531 | |
| chr11:46,593,562–46,594,345 | 106.6 kb | Distal (>10kb) Multiome | 845 | |
| chr11:46,616,855–46,618,064 | 83.3 kb | Distal (>10kb) Multiome | 823 | |
| chr11:46,664,502–46,665,016 | 35.8 kb | Distal (>10kb) Multiome | 126 | |
| chr11:46,674,791–46,675,556 | 25.5 kb | Distal (>10kb) Multiome | 308 | |
| chr11:46,700,262–46,701,275 | 114 bp | At TSS Multiome | 997 | |
| chr11:46,826,562–46,827,053 | 126.3 kb | Distal (>10kb) Multiome | 529 | |
| chr11:46,845,538–46,846,680 | 145.6 kb | Distal (>10kb) Multiome | 879 | |
| chr11:46,912,540–46,913,271 | 212.3 kb | Distal (>10kb) Multiome | 252 | |
| chr11:46,917,991–46,919,090 | 217.9 kb | Distal (>10kb) Multiome | 405 | |
| chr11:46,936,572–46,937,187 | 236.2 kb | Distal (>10kb) Multiome | 744 | |
| chr11:46,947,422–46,947,958 | 247.2 kb | Distal (>10kb) Multiome | 150 |
Genomic view of the ARHGAP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.