The protein encoded by this gene is a membrane-associated GTP-ase which localizes to the plasma membrane and is related to the ADP-ribosylation factor (ARF) and ARF-like (ARL) proteins. This gene plays a role in membrane trafficking between the trans-Golgi network and endosomes. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, May 2012]
Transcription factors with Perturb-seq knockdown data for ARFRP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ARFRP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ARFRP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:63,409,631–63,410,124 | 298.0 kb | Distal (>10kb) Multiome | 60 | |
| chr20:63,471,533–63,472,788 | 235.3 kb | Distal (>10kb) Multiome | 219 | |
| chr20:63,488,166–63,488,632 | 219.5 kb | Distal (>10kb) Multiome | 127 | |
| chr20:63,498,850–63,499,391 | 208.6 kb | Distal (>10kb) Multiome | 232 | |
| chr20:63,519,657–63,521,677 | 187.3 kb | Distal (>10kb) Multiome | 712 | |
| chr20:63,537,759–63,538,455 | 169.8 kb | Distal (>10kb) Multiome | 823 | |
| chr20:63,552,551–63,554,733 | 154.3 kb | Distal (>10kb) Multiome | 544 | |
| chr20:63,573,969–63,574,596 | 133.6 kb | Distal (>10kb) Multiome | 551 | |
| chr20:63,626,480–63,627,647 | 80.9 kb | Distal (>10kb) Multiome | 982 | |
| chr20:63,641,266–63,642,913 | 65.9 kb | Distal (>10kb) Multiome | 691 | |
| chr20:63,652,233–63,654,166 | 54.4 kb | Distal (>10kb) Multiome | 1011 | |
| chr20:63,657,813–63,658,939 | 49.5 kb | Distal (>10kb) Multiome | 1055 | |
| chr20:63,696,254–63,697,070 | 11.4 kb | Distal (>10kb) Multiome | 458 | |
| chr20:63,707,489–63,708,488 | 45 bp | At TSS Multiome | 1008 | |
| chr20:63,737,573–63,741,470 | 31.7 kb | Distal (>10kb) Multiome | 1098 | |
| chr20:63,775,216–63,775,997 | 67.6 kb | Distal (>10kb) Multiome | 257 | |
| chr20:63,830,341–63,832,721 | 123.4 kb | Distal (>10kb) Multiome | 628 | |
| chr20:63,846,273–63,846,790 | 138.6 kb | Distal (>10kb) Multiome | 487 | |
| chr20:63,864,234–63,865,991 | 157.2 kb | Distal (>10kb) Multiome | 1158 | |
| chr20:63,894,341–63,895,764 | 187.1 kb | Distal (>10kb) Multiome | 791 | |
| chr20:63,938,191–63,939,815 | 230.8 kb | Distal (>10kb) Multiome | 287 | |
| chr20:63,939,918–63,942,008 | 233.7 kb | Distal (>10kb) Multiome | 496 | |
| chr20:63,955,375–63,956,875 | 248.4 kb | Distal (>10kb) Multiome | 1107 | |
| chr20:63,956,976–63,958,127 | 249.7 kb | Distal (>10kb) Multiome | 709 | |
| chr20:63,969,149–63,970,667 | 262.0 kb | Distal (>10kb) Multiome | 764 | |
| chr20:63,973,660–63,974,150 | 266.0 kb | Distal (>10kb) Multiome | 767 | |
| chr20:63,980,541–63,981,488 | 273.2 kb | Distal (>10kb) Multiome | 986 |
Genomic view of the ARFRP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.