The protein encoded by this gene contains SAM, ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology (PH) domains. In vitro, this protein displays RHO-GAP and phosphatidylinositol (3,4,5) trisphosphate (PIP3)-dependent ARF-GAP activity. The encoded protein associates with the Golgi, and the ARF-GAP activity mediates changes in the Golgi and the formation of filopodia. It is thought to regulate the cell-specific trafficking of a receptor protein involved in apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]
Transcription factors with Perturb-seq knockdown data for ARAP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ARAP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ARAP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:72,534,428–72,535,106 | 217.5 kb | Distal (>10kb) Multiome | 152 | |
| chr11:72,584,069–72,584,889 | 167.9 kb | Distal (>10kb) Multiome | 98 | |
| chr11:72,589,653–72,590,682 | 162.1 kb | Distal (>10kb) Multiome | 303 | |
| chr11:72,642,014–72,643,645 | 109.3 kb | Distal (>10kb) Multiome | 594 | |
| chr11:72,683,647–72,685,043 | 68.2 kb | Distal (>10kb) Multiome | 428 | |
| chr11:72,722,329–72,722,710 | 29.8 kb | Distal (>10kb) Multiome | 323 | |
| chr11:72,752,008–72,752,857 | 126 bp | At TSS Multiome | 638 | |
| chr11:72,781,427–72,782,186 | 29.4 kb | Distal (>10kb) Multiome | 399 | |
| chr11:72,793,430–72,794,453 | 41.5 kb | Distal (>10kb) Multiome | 847 | |
| chr11:72,813,727–72,815,115 | 62.0 kb | Distal (>10kb) Multiome | 870 | |
| chr11:72,821,008–72,822,837 | 69.9 kb | Distal (>10kb) Multiome | 628 |
Genomic view of the ARAP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.