Enables protein serine/threonine kinase activity. Involved in negative regulation of apoptotic process; regulation of TOR signaling; and regulation of protein metabolic process. Predicted to be active in cytosol and mitochondrion. Biomarker of high grade glioma. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ARAF. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ARAF upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ARAF, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrX:47,321,409–47,321,883 | 239.6 kb | Distal (>10kb) Multiome | 127 | |
| chrX:47,361,756–47,362,456 | 199.0 kb | Distal (>10kb) Multiome | 297 | |
| chrX:47,381,691–47,382,470 | 179.0 kb | Distal (>10kb) Multiome | 17 | |
| chrX:47,482,474–47,483,311 | 78.4 kb | Distal (>10kb) Multiome | 573 | |
| chrX:47,523,425–47,523,870 | 37.6 kb | Distal (>10kb) Multiome | 403 | |
| chrX:47,556,126–47,556,602 | 4.9 kb | Proximal (<10kb) Multiome | 278 | |
| chrX:47,560,759–47,561,636 | 25 bp | At TSS Multiome | 638 | |
| chrX:47,619,457–47,620,174 | 58.7 kb | Distal (>10kb) Multiome | 643 | |
| chrX:47,623,578–47,624,031 | 62.7 kb | Distal (>10kb) Multiome | 183 | |
| chrX:47,650,269–47,651,363 | 89.6 kb | Distal (>10kb) Multiome | 552 | |
| chrX:47,658,568–47,659,484 | 97.8 kb | Distal (>10kb) Multiome | 753 | |
| chrX:47,836,213–47,837,023 | 275.5 kb | Distal (>10kb) Multiome | 544 |
Genomic view of the ARAF locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.