Enables 3'-5' RNA helicase activity and single-stranded RNA binding activity. Involved in mRNA splicing, via spliceosome. Located in nucleoplasm. Part of U2-type catalytic step 2 spliceosome. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for AQR. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = AQR upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of AQR, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:34,721,776–34,722,400 | 247.7 kb | Distal (>10kb) Multiome | 275 | |
| chr15:34,754,688–34,755,339 | 214.7 kb | Distal (>10kb) Multiome | 165 | |
| chr15:34,795,012–34,796,020 | 174.2 kb | Distal (>10kb) Multiome | 219 | |
| chr15:34,969,126–34,970,219 | 74 bp | At TSS Multiome | 886 | |
| chr15:34,976,144–34,976,499 | 6.4 kb | Proximal (<10kb) | 18 | |
| chr15:34,987,975–34,988,845 | 18.6 kb | Distal (>10kb) Multiome | 940 | |
| chr15:35,018,915–35,019,739 | 49.8 kb | Distal (>10kb) Multiome | 105 | |
| chr15:35,019,863–35,020,882 | 50.8 kb | Distal (>10kb) Multiome | 129 | |
| chr15:35,166,757–35,167,271 | 197.2 kb | Distal (>10kb) Multiome | 280 |
Genomic view of the AQR locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.