Enables glycerol channel activity; hydrogen peroxide channel activity; and water channel activity. Involved in several processes, including glycerol transmembrane transport; hydrogen peroxide transmembrane transport; and intracellular water homeostasis. Located in cell surface; endoplasmic reticulum; and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for AQP11. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = AQP11 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of AQP11, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:77,191,860–77,192,374 | 397.8 kb | Distal (>10kb) Multiome HiCAR | 447 | |
| chr11:77,411,314–77,412,382 | 178.0 kb | Distal (>10kb) Multiome | 405 | |
| chr11:77,436,791–77,437,318 | 152.8 kb | Distal (>10kb) Multiome | 44 | |
| chr11:77,473,004–77,474,837 | 115.8 kb | Distal (>10kb) Multiome | 769 | |
| chr11:77,555,382–77,556,090 | 34.1 kb | Distal (>10kb) Multiome | 138 | |
| chr11:77,589,259–77,590,628 | 183 bp | At TSS Multiome | 830 | |
| chr11:77,637,444–77,638,090 | 47.8 kb | Distal (>10kb) Multiome | 929 | |
| chr11:77,819,354–77,821,704 | 231.1 kb | Distal (>10kb) Multiome | 1047 |
Genomic view of the AQP11 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.