Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for APRG1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = APRG1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of APRG1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:37,175,555–37,176,875 | 209.3 kb | Distal (>10kb) Multiome | 907 | |
| chr3:37,242,726–37,244,363 | 142.3 kb | Distal (>10kb) Multiome | 969 | |
| chr3:37,375,227–37,375,671 | 9.9 kb | Proximal (<10kb) | 78 | |
| chr3:37,451,532–37,454,321 | 66.5 kb | Distal (>10kb) Multiome | 422 | |
| chr3:37,504,384–37,505,247 | 119.2 kb | Distal (>10kb) Multiome | 181 | |
| chr3:37,531,867–37,532,817 | 146.8 kb | Distal (>10kb) Multiome | 142 |
Genomic view of the APRG1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.