This gene is a member of the apolipoprotein family. Members of this protein family are involved in the transport and metabolism of lipids. The encoded protein associates with HDL, LDL and VLDL lipoproteins and is characterized by chondroitin-sulfate glycosylation. This protein may be involved in preventing lipid accumulation in the myocardium in obese and diabetic patients. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 3, 4, 5, 12 and 16.[provided by RefSeq, Sep 2009]
Transcription factors with Perturb-seq knockdown data for APOO. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = APOO upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of APOO, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrX:23,667,233–23,667,983 | 240.5 kb | Distal (>10kb) Multiome | 695 | |
| chrX:23,742,772–23,743,685 | 164.6 kb | Distal (>10kb) Multiome HiCAR | 635 | |
| chrX:23,782,718–23,783,632 | 124.8 kb | Distal (>10kb) Multiome HiCAR | 741 | |
| chrX:23,907,232–23,908,257 | 47 bp | At TSS Multiome | 770 | |
| chrX:24,024,718–24,026,097 | 117.5 kb | Distal (>10kb) Multiome | 765 | |
| chrX:24,054,185–24,055,227 | 146.7 kb | Distal (>10kb) Multiome | 763 | |
| chrX:24,149,214–24,150,721 | 242.4 kb | Distal (>10kb) Multiome | 710 |
Genomic view of the APOO locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.