Enables arylesterase activity. Located in cell surface and membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for APMAP. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = APMAP upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of APMAP, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:24,992,035–24,993,195 | 7 bp | At TSS Multiome | 943 | |
| chr20:24,994,716–24,995,335 | 2.0 kb | Proximal (<10kb) | 396 | |
| chr20:25,081,073–25,082,266 | 88.6 kb | Distal (>10kb) Multiome | 338 | |
| chr20:25,195,309–25,197,066 | 203.0 kb | Distal (>10kb) Multiome HiCAR | 970 | |
| chr20:25,247,007–25,249,001 | 255.4 kb | Distal (>10kb) Multiome | 1035 |
Genomic view of the APMAP locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.