This gene encodes a member of the G protein-coupled receptor gene family. The encoded protein is related to the angiotensin receptor, but is actually an apelin receptor that inhibits adenylate cyclase activity and plays a counter-regulatory role against the pressure action of angiotensin II by exerting hypertensive effect. It functions in the cardiovascular and central nervous systems, in glucose metabolism, in embryonic and tumor angiogenesis and as a human immunodeficiency virus (HIV-1) coreceptor. Two transcript variants resulting from alternative splicing have been identified. [provided by RefSeq, Jul 2009]
Transcription factors with Perturb-seq knockdown data for APLNR. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = APLNR upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of APLNR, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:57,212,992–57,214,202 | 23.7 kb | Distal (>10kb) Multiome | 248 | |
| chr11:57,230,803–57,231,387 | 5.9 kb | Proximal (<10kb) | 36 | |
| chr11:57,236,823–57,238,006 | 236 bp | At TSS Multiome | 256 | |
| chr11:57,240,506–57,241,270 | 3.3 kb | Proximal (<10kb) | 161 | |
| chr11:57,242,064–57,242,828 | 5.2 kb | Proximal (<10kb) Multiome | 232 | |
| chr11:57,310,924–57,312,111 | 74.3 kb | Distal (>10kb) Multiome | 620 | |
| chr11:57,323,847–57,325,914 | 87.7 kb | Distal (>10kb) Multiome | 790 | |
| chr11:57,335,065–57,336,267 | 98.5 kb | Distal (>10kb) Multiome | 689 | |
| chr11:57,345,508–57,346,149 | 108.6 kb | Distal (>10kb) Multiome | 241 | |
| chr11:57,349,624–57,350,269 | 112.7 kb | Distal (>10kb) Multiome | 357 | |
| chr11:57,426,113–57,427,448 | 189.8 kb | Distal (>10kb) Multiome | 451 | |
| chr11:57,457,029–57,457,825 | 220.2 kb | Distal (>10kb) Multiome | 458 | |
| chr11:57,460,127–57,461,576 | 223.3 kb | Distal (>10kb) Multiome | 418 | |
| chr11:57,480,236–57,481,014 | 243.3 kb | Distal (>10kb) Multiome | 300 | |
| chr11:57,482,336–57,483,518 | 245.9 kb | Distal (>10kb) Multiome | 338 | |
| chr11:57,499,261–57,500,331 | 262.5 kb | Distal (>10kb) Multiome | 548 | |
| chr11:57,530,326–57,531,572 | 293.7 kb | Distal (>10kb) Multiome | 824 |
Genomic view of the APLNR locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.