Predicted to enable Wnt-protein binding activity. Predicted to be involved in negative regulation of Wnt signaling pathway. Predicted to be located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for APCDD1L. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = APCDD1L upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of APCDD1L, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:58,228,258–58,229,094 | 286.4 kb | Distal (>10kb) Multiome | 184 | |
| chr20:58,308,722–58,310,416 | 205.4 kb | Distal (>10kb) Multiome | 732 | |
| chr20:58,331,681–58,332,501 | 182.9 kb | Distal (>10kb) Multiome | 115 | |
| chr20:58,388,753–58,389,913 | 126.0 kb | Distal (>10kb) Multiome | 887 | |
| chr20:58,482,394–58,483,281 | 32.5 kb | Distal (>10kb) Multiome | 155 | |
| chr20:58,514,461–58,515,572 | 16 bp | At TSS Multiome | 173 | |
| chr20:58,523,004–58,524,066 | 8.3 kb | Proximal (<10kb) Multiome | 197 | |
| chr20:58,546,673–58,547,327 | 31.9 kb | Distal (>10kb) Multiome | 69 | |
| chr20:58,649,950–58,652,788 | 136.0 kb | Distal (>10kb) Multiome | 1208 | |
| chr20:58,669,288–58,669,967 | 154.5 kb | Distal (>10kb) Multiome | 158 | |
| chr20:58,692,413–58,693,477 | 177.6 kb | Distal (>10kb) Multiome | 317 |
Genomic view of the APCDD1L locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.