This locus encodes an inhibitor of the Wnt signaling pathway. Mutations at this locus have been associated with hereditary hypotrichosis simplex. Increased expression of this gene may also be associated with colorectal carcinogenesis.[provided by RefSeq, Sep 2010]
Transcription factors with Perturb-seq knockdown data for APCDD1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = APCDD1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of APCDD1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr18:10,032,431–10,032,888 | 422.1 kb | Distal (>10kb) Multiome HiCAR | 165 | |
| chr18:10,406,100–10,406,886 | 48.2 kb | Distal (>10kb) Multiome | 207 | |
| chr18:10,453,745–10,455,261 | 72 bp | At TSS Multiome | 375 | |
| chr18:10,525,772–10,526,686 | 71.5 kb | Distal (>10kb) Multiome | 732 |
Genomic view of the APCDD1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.