Involved in endosomal transport. Located in several cellular components, including cytosol; late endosome; and lysosome. Part of AP-type membrane coat adaptor complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for AP5M1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = AP5M1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of AP5M1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:56,552,658–56,553,598 | 716.0 kb | Distal (>10kb) Multiome HiCAR | 60 | |
| chr14:56,579,396–56,580,264 | 689.3 kb | Distal (>10kb) Multiome HiCAR | 723 | |
| chr14:56,998,512–56,999,273 | 270.1 kb | Distal (>10kb) Multiome | 139 | |
| chr14:57,049,791–57,050,396 | 218.9 kb | Distal (>10kb) Multiome | 43 | |
| chr14:57,268,159–57,269,344 | 224 bp | At TSS Multiome | 916 | |
| chr14:57,364,988–57,365,748 | 96.4 kb | Distal (>10kb) Multiome | 54 | |
| chr14:57,389,614–57,391,598 | 121.6 kb | Distal (>10kb) Multiome | 779 | |
| chr14:57,473,378–57,474,215 | 204.9 kb | Distal (>10kb) Multiome | 31 |
Genomic view of the AP5M1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.