This gene encodes a subunit of the heterotetrameric adaptor-related protein comlex 3 (AP-3), which belongs to the adaptor complexes medium subunits family. The AP-3 complex plays a role in protein trafficking to lysosomes and specialized organelles. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Aug 2008]
Transcription factors with Perturb-seq knockdown data for AP3M2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = AP3M2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of AP3M2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:41,895,762–41,897,697 | 257.0 kb | Distal (>10kb) Multiome | 781 | |
| chr8:42,010,489–42,011,119 | 142.3 kb | Distal (>10kb) Multiome | 127 | |
| chr8:42,050,725–42,052,921 | 100.8 kb | Distal (>10kb) Multiome | 1042 | |
| chr8:42,139,747–42,140,990 | 12.4 kb | Distal (>10kb) Multiome | 779 | |
| chr8:42,151,983–42,153,808 | 131 bp | At TSS Multiome | 975 | |
| chr8:42,270,718–42,271,870 | 118.2 kb | Distal (>10kb) Multiome | 668 | |
| chr8:42,337,948–42,339,165 | 185.4 kb | Distal (>10kb) Multiome | 710 | |
| chr8:42,376,919–42,377,769 | 224.3 kb | Distal (>10kb) Multiome HiCAR | 159 | |
| chr8:42,391,151–42,392,597 | 238.7 kb | Distal (>10kb) Multiome | 831 |
Genomic view of the AP3M2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.