Adaptor protein complex 3 (AP-3 complex) is a heterotrimeric protein complex involved in the formation of clathrin-coated synaptic vesicles. The protein encoded by this gene represents the beta subunit of the neuron-specific AP-3 complex and was first identified as the target antigen in human paraneoplastic neurologic disorders. The encoded subunit binds clathrin and is phosphorylated by a casein kinase-like protein, which mediates synaptic vesicle coat assembly. Defects in this gene are a cause of early-onset epileptic encephalopathy. [provided by RefSeq, Feb 2017]
Transcription factors with Perturb-seq knockdown data for AP3B2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = AP3B2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of AP3B2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:82,571,710–82,572,201 | 138.1 kb | Distal (>10kb) Multiome | 194 | |
| chr15:82,647,462–82,648,736 | 61.8 kb | Distal (>10kb) Multiome | 511 | |
| chr15:82,679,753–82,681,281 | 29.4 kb | Distal (>10kb) Multiome | 495 | |
| chr15:82,699,869–82,700,076 | 9.8 kb | Proximal (<10kb) | 73 | |
| chr15:82,708,066–82,708,566 | 1.4 kb | Proximal (<10kb) | 15 | |
| chr15:82,708,766–82,710,416 | 229 bp | At TSS Multiome | 725 | |
| chr15:82,750,200–82,750,777 | 40.6 kb | Distal (>10kb) Multiome | 790 | |
| chr15:82,809,212–82,810,601 | 99.7 kb | Distal (>10kb) Multiome | 808 | |
| chr15:82,849,476–82,850,366 | 139.9 kb | Distal (>10kb) Multiome | 450 | |
| chr15:82,910,611–82,911,202 | 201.1 kb | Distal (>10kb) Multiome | 35 | |
| chr15:82,952,161–82,953,316 | 242.8 kb | Distal (>10kb) Multiome | 430 | |
| chr15:82,985,830–82,986,497 | 276.2 kb | Distal (>10kb) Multiome | 853 |
Genomic view of the AP3B2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.