One of two major clathrin-associated adaptor complexes, AP-2, is a heterotetramer which is associated with the plasma membrane. This complex is composed of two large chains, a medium chain, and a small chain. This gene encodes the small chain of this complex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Transcription factors with Perturb-seq knockdown data for AP2S1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = AP2S1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of AP2S1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:46,587,845–46,588,467 | 262.7 kb | Distal (>10kb) Multiome | 21 | |
| chr19:46,600,411–46,601,577 | 249.8 kb | Distal (>10kb) Multiome | 1006 | |
| chr19:46,633,826–46,635,061 | 216.5 kb | Distal (>10kb) Multiome | 365 | |
| chr19:46,638,437–46,639,929 | 211.8 kb | Distal (>10kb) Multiome | 741 | |
| chr19:46,659,987–46,662,280 | 189.5 kb | Distal (>10kb) Multiome | 691 | |
| chr19:46,696,773–46,698,048 | 153.3 kb | Distal (>10kb) Multiome | 408 | |
| chr19:46,713,710–46,714,718 | 136.7 kb | Distal (>10kb) Multiome | 566 | |
| chr19:46,716,676–46,717,696 | 133.7 kb | Distal (>10kb) Multiome | 487 | |
| chr19:46,745,601–46,746,962 | 104.4 kb | Distal (>10kb) Multiome | 561 | |
| chr19:46,787,215–46,789,013 | 62.2 kb | Distal (>10kb) Multiome | 944 | |
| chr19:46,840,568–46,840,817 | 9.5 kb | Proximal (<10kb) | 295 | |
| chr19:46,850,211–46,851,336 | 4 bp | At TSS Multiome | 946 | |
| chr19:46,855,920–46,856,711 | 5.4 kb | Proximal (<10kb) Multiome | 610 | |
| chr19:46,859,815–46,861,611 | 9.5 kb | Proximal (<10kb) Multiome | 1061 | |
| chr19:47,019,502–47,020,076 | 168.9 kb | Distal (>10kb) Multiome HiCAR | 188 | |
| chr19:47,035,599–47,036,293 | 185.1 kb | Distal (>10kb) Multiome | 627 | |
| chr19:47,047,837–47,048,980 | 197.1 kb | Distal (>10kb) Multiome | 760 | |
| chr19:47,058,561–47,059,308 | 208.1 kb | Distal (>10kb) Multiome | 357 | |
| chr19:47,111,821–47,113,936 | 261.3 kb | Distal (>10kb) Multiome | 1117 | |
| chr19:47,130,439–47,131,651 | 280.0 kb | Distal (>10kb) Multiome | 908 |
Genomic view of the AP2S1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.