The protein encoded by this gene is part of the clathrin coat assembly complex which links clathrin to receptors in coated vesicles. These vesicles are involved in endocytosis and Golgi processing. This protein, as well as beta-prime-adaptin, gamma-adaptin, and the medium (mu) chain AP47, form the AP-1 assembly protein complex located at the Golgi vesicle. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for AP1S1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = AP1S1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of AP1S1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:100,874,652–100,875,664 | 279.4 kb | Distal (>10kb) Multiome | 1020 | |
| chr7:100,888,882–100,891,520 | 264.6 kb | Distal (>10kb) Multiome | 1077 | |
| chr7:100,894,188–100,896,392 | 258.4 kb | Distal (>10kb) Multiome | 609 | |
| chr7:100,896,481–100,897,567 | 257.4 kb | Distal (>10kb) Multiome | 538 | |
| chr7:101,085,076–101,085,958 | 69.0 kb | Distal (>10kb) Multiome | 732 | |
| chr7:101,153,861–101,155,183 | 5 bp | At TSS Multiome | 670 | |
| chr7:101,162,599–101,164,796 | 8.6 kb | Proximal (<10kb) Multiome | 654 | |
| chr7:101,165,195–101,166,546 | 11.2 kb | Distal (>10kb) Multiome | 980 | |
| chr7:101,173,985–101,174,835 | 19.7 kb | Distal (>10kb) Multiome | 323 | |
| chr7:101,216,957–101,218,626 | 63.3 kb | Distal (>10kb) Multiome | 918 | |
| chr7:101,232,007–101,233,160 | 78.1 kb | Distal (>10kb) Multiome | 304 | |
| chr7:101,244,041–101,245,521 | 90.5 kb | Distal (>10kb) Multiome | 989 | |
| chr7:101,251,898–101,252,786 | 97.9 kb | Distal (>10kb) Multiome | 751 | |
| chr7:101,282,845–101,283,297 | 128.7 kb | Distal (>10kb) Multiome | 300 | |
| chr7:101,294,017–101,295,035 | 139.9 kb | Distal (>10kb) Multiome | 188 | |
| chr7:101,299,826–101,300,551 | 145.6 kb | Distal (>10kb) Multiome | 147 | |
| chr7:101,302,606–101,303,724 | 148.4 kb | Distal (>10kb) Multiome | 167 | |
| chr7:101,308,000–101,309,265 | 153.9 kb | Distal (>10kb) Multiome | 357 | |
| chr7:101,321,440–101,322,377 | 167.4 kb | Distal (>10kb) Multiome | 537 | |
| chr7:101,362,703–101,363,475 | 208.4 kb | Distal (>10kb) Multiome | 258 | |
| chr7:101,363,545–101,364,217 | 209.6 kb | Distal (>10kb) Multiome | 584 | |
| chr7:101,411,116–101,411,868 | 257.0 kb | Distal (>10kb) Multiome | 307 | |
| chr7:101,420,273–101,420,839 | 266.2 kb | Distal (>10kb) Multiome | 54 |
Genomic view of the AP1S1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.