Annexin VI belongs to a family of calcium-dependent membrane and phospholipid binding proteins. Several members of the annexin family have been implicated in membrane-related events along exocytotic and endocytotic pathways. The annexin VI gene is approximately 60 kbp long and contains 26 exons. It encodes a protein of about 68 kDa that consists of eight 68-amino acid repeats separated by linking sequences of variable lengths. It is highly similar to human annexins I and II sequences, each of which contain four such repeats. Annexin VI has been implicated in mediating the endosome aggregation and vesicle fusion in secreting epithelia during exocytosis. Alternatively spliced transcript variants have been described. [provided by RefSeq, Aug 2010]
Transcription factors with Perturb-seq knockdown data for ANXA6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ANXA6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ANXA6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:151,002,371–151,003,402 | 154.9 kb | Distal (>10kb) Multiome | 132 | |
| chr5:151,020,249–151,021,200 | 137.3 kb | Distal (>10kb) Multiome | 522 | |
| chr5:151,080,524–151,081,640 | 76.8 kb | Distal (>10kb) Multiome | 916 | |
| chr5:151,157,085–151,158,664 | 14 bp | At TSS Multiome | 760 | |
| chr5:151,164,674–151,165,094 | 6.9 kb | Proximal (<10kb) | 279 | |
| chr5:151,223,077–151,224,282 | 66.2 kb | Distal (>10kb) Multiome | 662 | |
| chr5:151,252,199–151,253,942 | 95.1 kb | Distal (>10kb) Multiome | 746 | |
| chr5:151,348,447–151,349,638 | 191.2 kb | Distal (>10kb) Multiome | 138 | |
| chr5:151,405,271–151,406,618 | 247.8 kb | Distal (>10kb) Multiome | 175 | |
| chr5:151,447,360–151,448,441 | 289.8 kb | Distal (>10kb) Multiome | 900 |
Genomic view of the ANXA6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.