Predicted to enable signaling receptor activity. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ANXA2R. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ANXA2R upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ANXA2R, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:43,033,756–43,034,480 | 5.8 kb | Proximal (<10kb) | 72 | |
| chr5:43,038,347–43,038,852 | 1.5 kb | Proximal (<10kb) | 203 | |
| chr5:43,039,430–43,041,066 | at TSS | At TSS | 830 | |
| chr5:43,041,652–43,043,529 | 1.3 kb | Proximal (<10kb) | 897 | |
| chr5:43,044,193–43,044,964 | 3.9 kb | Proximal (<10kb) | 122 | |
| chr5:43,045,375–43,045,565 | 5.1 kb | Proximal (<10kb) | 42 |
Genomic view of the ANXA2R locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.