Enables RNA binding activity. Involved in nucleocytoplasmic transport. Located in endoplasmic reticulum; nucleus; and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ANP32A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ANP32A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ANP32A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:68,542,811–68,543,454 | 277.8 kb | Distal (>10kb) Multiome | 155 | |
| chr15:68,559,409–68,560,165 | 261.1 kb | Distal (>10kb) Multiome | 531 | |
| chr15:68,579,077–68,579,774 | 241.7 kb | Distal (>10kb) Multiome | 304 | |
| chr15:68,650,921–68,651,400 | 169.7 kb | Distal (>10kb) Multiome | 208 | |
| chr15:68,795,318–68,795,861 | 25.4 kb | Distal (>10kb) Multiome | 326 | |
| chr15:68,817,340–68,819,598 | 2.2 kb | Proximal (<10kb) Multiome | 755 | |
| chr15:68,820,797–68,821,601 | 163 bp | At TSS Multiome | 618 | |
| chr15:68,875,234–68,876,172 | 54.9 kb | Distal (>10kb) Multiome | 433 | |
| chr15:68,991,545–68,992,257 | 170.9 kb | Distal (>10kb) Multiome | 290 | |
| chr15:69,059,802–69,060,199 | 239.2 kb | Distal (>10kb) Multiome | 71 | |
| chr15:69,074,015–69,074,755 | 253.7 kb | Distal (>10kb) Multiome | 443 | |
| chr15:69,087,968–69,090,194 | 267.6 kb | Distal (>10kb) Multiome | 309 | |
| chr15:69,117,299–69,117,876 | 296.8 kb | Distal (>10kb) Multiome | 153 |
Genomic view of the ANP32A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.