Enables intracellularly calcium-gated chloride channel activity. Involved in chloride transmembrane transport. Located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ANO4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ANO4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ANO4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:100,573,087–100,574,669 | 143.7 kb | Distal (>10kb) Multiome | 880 | |
| chr12:100,715,591–100,717,971 | 265 bp | At TSS Multiome | 353 | |
| chr12:100,718,168–100,718,581 | 643 bp | At TSS | 39 | |
| chr12:100,724,170–100,724,492 | 6.6 kb | Proximal (<10kb) | 13 | |
| chr12:100,895,786–100,896,670 | 178.7 kb | Distal (>10kb) Multiome | 74 | |
| chr12:100,935,598–100,936,940 | 218.6 kb | Distal (>10kb) Multiome | 64 | |
| chr12:100,986,790–100,988,527 | 270.6 kb | Distal (>10kb) Multiome | 388 |
Genomic view of the ANO4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.