Predicted to be located in cytoplasm. Predicted to be active in cilium. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ANKS3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ANKS3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ANKS3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:4,474,111–4,474,929 | 259.6 kb | Distal (>10kb) Multiome | 626 | |
| chr16:4,476,027–4,477,237 | 257.8 kb | Distal (>10kb) Multiome | 841 | |
| chr16:4,537,639–4,538,998 | 195.6 kb | Distal (>10kb) Multiome | 1087 | |
| chr16:4,585,331–4,585,992 | 148.6 kb | Distal (>10kb) Multiome | 223 | |
| chr16:4,613,912–4,617,164 | 119.3 kb | Distal (>10kb) Multiome | 1079 | |
| chr16:4,624,301–4,625,703 | 109.5 kb | Distal (>10kb) Multiome | 866 | |
| chr16:4,693,016–4,694,663 | 40.6 kb | Distal (>10kb) Multiome | 730 | |
| chr16:4,733,836–4,735,221 | 208 bp | At TSS Multiome | 858 | |
| chr16:4,766,728–4,767,628 | 33.0 kb | Distal (>10kb) Multiome | 795 | |
| chr16:4,768,438–4,769,162 | 34.6 kb | Distal (>10kb) Multiome | 677 | |
| chr16:4,801,836–4,803,175 | 68.1 kb | Distal (>10kb) Multiome | 743 | |
| chr16:4,846,559–4,848,209 | 113.2 kb | Distal (>10kb) Multiome | 803 | |
| chr16:4,936,143–4,937,673 | 203.1 kb | Distal (>10kb) Multiome | 655 | |
| chr16:4,943,173–4,943,813 | 209.2 kb | Distal (>10kb) Multiome | 609 | |
| chr16:4,957,489–4,958,782 | 223.9 kb | Distal (>10kb) Multiome | 802 | |
| chr16:5,010,592–5,011,132 | 276.6 kb | Distal (>10kb) Multiome | 136 | |
| chr16:5,033,461–5,034,081 | 299.7 kb | Distal (>10kb) Multiome | 932 |
Genomic view of the ANKS3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.