Predicted to enable protein kinase regulator activity. Predicted to be involved in positive regulation of erythrocyte differentiation and regulation of intracellular signal transduction. Predicted to act upstream of or within nucleocytoplasmic transport and regulation of protein kinase activity. Predicted to be located in midbody. Predicted to be active in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for ANKRD54. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ANKRD54 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ANKRD54, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr22:37,545,569–37,546,885 | 303.0 kb | Distal (>10kb) Multiome | 682 | |
| chr22:37,559,893–37,560,965 | 289.0 kb | Distal (>10kb) Multiome | 589 | |
| chr22:37,569,013–37,570,549 | 279.8 kb | Distal (>10kb) Multiome | 695 | |
| chr22:37,608,044–37,609,455 | 240.5 kb | Distal (>10kb) Multiome | 920 | |
| chr22:37,639,157–37,639,951 | 209.8 kb | Distal (>10kb) Multiome | 427 | |
| chr22:37,658,172–37,659,508 | 190.7 kb | Distal (>10kb) Multiome | 722 | |
| chr22:37,674,916–37,675,641 | 173.9 kb | Distal (>10kb) Multiome | 607 | |
| chr22:37,676,590–37,677,674 | 172.1 kb | Distal (>10kb) Multiome | 655 | |
| chr22:37,686,104–37,686,784 | 162.9 kb | Distal (>10kb) Multiome | 866 | |
| chr22:37,696,496–37,697,685 | 152.4 kb | Distal (>10kb) Multiome | 428 | |
| chr22:37,745,641–37,746,995 | 103.2 kb | Distal (>10kb) Multiome | 627 | |
| chr22:37,802,124–37,802,989 | 46.9 kb | Distal (>10kb) Multiome | 603 | |
| chr22:37,804,679–37,805,768 | 44.1 kb | Distal (>10kb) Multiome | 763 | |
| chr22:37,807,436–37,808,267 | 41.5 kb | Distal (>10kb) Multiome | 766 | |
| chr22:37,817,672–37,819,114 | 31.4 kb | Distal (>10kb) Multiome | 713 | |
| chr22:37,824,524–37,825,593 | 24.3 kb | Distal (>10kb) Multiome | 173 | |
| chr22:37,843,748–37,844,743 | 4.9 kb | Proximal (<10kb) Multiome | 798 | |
| chr22:37,849,215–37,849,709 | 65 bp | At TSS Multiome | 753 | |
| chr22:37,905,849–37,906,846 | 56.9 kb | Distal (>10kb) Multiome | 552 | |
| chr22:37,933,777–37,934,256 | 84.8 kb | Distal (>10kb) Multiome | 679 | |
| chr22:37,953,153–37,954,120 | 104.3 kb | Distal (>10kb) Multiome | 617 | |
| chr22:37,983,021–37,985,110 | 135.1 kb | Distal (>10kb) Multiome | 228 | |
| chr22:38,052,312–38,052,803 | 203.2 kb | Distal (>10kb) Multiome | 529 | |
| chr22:38,057,008–38,057,702 | 208.0 kb | Distal (>10kb) Multiome | 656 | |
| chr22:38,080,912–38,081,618 | 231.8 kb | Distal (>10kb) Multiome | 175 | |
| chr22:38,097,697–38,098,236 | 248.6 kb | Distal (>10kb) Multiome | 186 |
Genomic view of the ANKRD54 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.