Transcription factors with Perturb-seq knockdown data for ANKRD18B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ANKRD18B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ANKRD18B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:33,264,068–33,265,475 | 259.4 kb | Distal (>10kb) Multiome | 790 | |
| chr9:33,290,056–33,291,152 | 233.8 kb | Distal (>10kb) Multiome | 1075 | |
| chr9:33,381,203–33,381,714 | 142.7 kb | Distal (>10kb) Multiome | 134 | |
| chr9:33,447,056–33,448,058 | 76.7 kb | Distal (>10kb) Multiome | 547 | |
| chr9:33,452,742–33,453,295 | 71.2 kb | Distal (>10kb) Multiome | 374 | |
| chr9:33,473,593–33,474,250 | 50.3 kb | Distal (>10kb) Multiome | 635 | |
| chr9:33,515,277–33,515,972 | 8.3 kb | Proximal (<10kb) | 49 | |
| chr9:33,523,393–33,524,316 | 417 bp | At TSS Multiome | 303 | |
| chr9:33,676,675–33,677,521 | 152.9 kb | Distal (>10kb) Multiome | 242 | |
| chr9:33,721,959–33,722,424 | 197.9 kb | Distal (>10kb) Multiome | 461 | |
| chr9:33,816,538–33,818,390 | 292.8 kb | Distal (>10kb) Multiome | 924 |
Genomic view of the ANKRD18B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.