Transcription factors with Perturb-seq knockdown data for ANKRD18A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ANKRD18A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ANKRD18A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:38,380,130–38,381,754 | 239.6 kb | Distal (>10kb) Multiome | 696 | |
| chr9:38,392,279–38,393,206 | 227.9 kb | Distal (>10kb) Multiome | 749 | |
| chr9:38,423,581–38,424,783 | 196.3 kb | Distal (>10kb) Multiome | 342 | |
| chr9:38,427,089–38,427,935 | 193.1 kb | Distal (>10kb) Multiome | 164 | |
| chr9:38,433,915–38,434,850 | 186.1 kb | Distal (>10kb) Multiome HiCAR | 31 | |
| chr9:38,619,665–38,622,690 | 175 bp | At TSS Multiome | 761 | |
| chr9:38,672,308–38,672,940 | 52.1 kb | Distal (>10kb) Multiome | 541 | |
| chr9:38,689,638–38,690,086 | 69.2 kb | Distal (>10kb) Multiome | 159 | |
| chr9:39,809,298–39,810,116 | 1189.1 kb | Distal (>10kb) Multiome HiCAR | 93 |
Genomic view of the ANKRD18A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.