The protein encoded by this gene is a member of the ankyrin repeat domain (ANKRD) 13 family, which currently consists of four proteins containing ubiquitin-interacting motifs. These proteins are integral membrane proteins that bind specifically to Lys-63-linked ubiquitin chains on membrane-bound proteins, targeting those proteins for rapid internalization. [provided by RefSeq, Dec 2016]
Transcription factors with Perturb-seq knockdown data for ANKRD13D. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ANKRD13D upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ANKRD13D, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:67,023,002–67,023,688 | 265.9 kb | Distal (>10kb) Multiome | 243 | |
| chr11:67,056,596–67,057,312 | 232.4 kb | Distal (>10kb) Multiome HiCAR | 382 | |
| chr11:67,071,470–67,071,999 | 217.5 kb | Distal (>10kb) Multiome HiCAR | 302 | |
| chr11:67,117,553–67,120,314 | 170.2 kb | Distal (>10kb) Multiome | 762 | |
| chr11:67,239,493–67,240,241 | 49.4 kb | Distal (>10kb) Multiome | 792 | |
| chr11:67,265,898–67,267,077 | 22.8 kb | Distal (>10kb) Multiome | 471 | |
| chr11:67,288,260–67,289,971 | 138 bp | At TSS Multiome | 985 | |
| chr11:67,302,488–67,304,170 | 14.1 kb | Distal (>10kb) Multiome | 661 | |
| chr11:67,316,992–67,318,501 | 28.4 kb | Distal (>10kb) Multiome | 918 | |
| chr11:67,352,967–67,354,228 | 64.4 kb | Distal (>10kb) Multiome | 781 | |
| chr11:67,372,171–67,373,596 | 83.8 kb | Distal (>10kb) Multiome | 497 | |
| chr11:67,391,276–67,392,428 | 102.6 kb | Distal (>10kb) Multiome | 957 | |
| chr11:67,401,038–67,402,351 | 112.6 kb | Distal (>10kb) Multiome | 741 | |
| chr11:67,420,418–67,421,666 | 131.9 kb | Distal (>10kb) Multiome | 648 | |
| chr11:67,428,036–67,428,950 | 139.1 kb | Distal (>10kb) Multiome | 813 | |
| chr11:67,443,182–67,444,063 | 154.3 kb | Distal (>10kb) Multiome | 612 | |
| chr11:67,464,410–67,465,252 | 175.5 kb | Distal (>10kb) Multiome | 710 | |
| chr11:67,468,551–67,469,666 | 180.0 kb | Distal (>10kb) Multiome | 774 | |
| chr11:67,482,830–67,483,745 | 193.9 kb | Distal (>10kb) Multiome | 969 | |
| chr11:67,504,073–67,506,408 | 217.0 kb | Distal (>10kb) Multiome | 769 | |
| chr11:67,507,504–67,509,030 | 219.1 kb | Distal (>10kb) Multiome | 897 | |
| chr11:67,583,474–67,584,777 | 294.4 kb | Distal (>10kb) Multiome | 633 |
Genomic view of the ANKRD13D locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.