Angiopoietins are members of the vascular endothelial growth factor family and the only known growth factors largely specific for vascular endothelium. Angiopoietin-1, angiopoietin-2, and angiopoietin-4 participate in the formation of blood vessels. The protein encoded by this gene is another member of the angiopoietin family that is widely expressed in adult tissues with mRNA levels highest in highly vascularized tissues. This protein was found to be a secretory protein that does not act as an endothelial cell mitogen in vitro. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for ANGPTL1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ANGPTL1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ANGPTL1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:178,581,331–178,581,873 | 287.6 kb | Distal (>10kb) Multiome | 139 | |
| chr1:178,724,480–178,726,551 | 142.9 kb | Distal (>10kb) Multiome | 861 | |
| chr1:178,869,214–178,869,590 | at TSS | At TSS | 57 | |
| chr1:179,002,311–179,003,353 | 133.6 kb | Distal (>10kb) Multiome | 522 | |
| chr1:179,025,292–179,027,102 | 156.7 kb | Distal (>10kb) Multiome | 930 | |
| chr1:179,081,467–179,083,301 | 212.8 kb | Distal (>10kb) Multiome | 968 | |
| chr1:179,087,385–179,088,206 | 218.5 kb | Distal (>10kb) Multiome | 194 |
Genomic view of the ANGPTL1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.