This gene encodes a secreted glycoprotein that belongs to the angiopoietin family. Members of this family play important roles in vascular development and angiogenesis. All angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. The protein encoded by this gene is a secreted glycoprotein that activates the receptor by inducing its tyrosine phosphorylation. It plays a critical role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme and inhibits endothelial permeability. The protein also contributes to blood vessel maturation and stability, and may be involved in early development of the heart. Mutations in this gene are associated with hereditary angioedema. [provided by RefSeq, Aug 2020]
Transcription factors with Perturb-seq knockdown data for ANGPT1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ANGPT1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ANGPT1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:107,490,012–107,490,657 | 7.3 kb | Proximal (<10kb) | 146 | |
| chr8:107,494,901–107,495,301 | 2.6 kb | Proximal (<10kb) | 126 | |
| chr8:107,495,885–107,496,330 | 1.6 kb | Proximal (<10kb) | 214 | |
| chr8:107,496,442–107,496,638 | 1.3 kb | Proximal (<10kb) | 38 | |
| chr8:107,497,026–107,497,661 | 256 bp | At TSS | 229 | |
| chr8:107,497,778–107,498,166 | at TSS | At TSS | 187 | |
| chr8:107,499,524–107,499,724 | 1.6 kb | Proximal (<10kb) | 119 |
Genomic view of the ANGPT1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.