Enables eukaryotic initiation factor 4E binding activity and protein domain specific binding activity. Located in several cellular components, including cis-Golgi network; endoplasmic reticulum; and perinuclear region of cytoplasm. Is active in mitochondrial outer membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ANGEL1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ANGEL1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ANGEL1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:76,563,507–76,564,002 | 249.1 kb | Distal (>10kb) Multiome | 13 | |
| chr14:76,695,366–76,696,205 | 117.1 kb | Distal (>10kb) Multiome | 33 | |
| chr14:76,761,176–76,762,367 | 51.2 kb | Distal (>10kb) Multiome | 486 | |
| chr14:76,784,691–76,785,144 | 27.9 kb | Distal (>10kb) Multiome | 318 | |
| chr14:76,812,161–76,813,291 | 17 bp | At TSS Multiome | 878 | |
| chr14:76,913,323–76,913,886 | 100.8 kb | Distal (>10kb) Multiome | 352 | |
| chr14:76,924,332–76,925,072 | 111.8 kb | Distal (>10kb) Multiome | 256 | |
| chr14:76,947,024–76,947,904 | 134.5 kb | Distal (>10kb) Multiome | 690 | |
| chr14:76,955,827–76,957,395 | 143.7 kb | Distal (>10kb) Multiome | 873 | |
| chr14:76,961,044–76,962,678 | 149.1 kb | Distal (>10kb) Multiome | 848 | |
| chr14:76,968,574–76,969,080 | 156.0 kb | Distal (>10kb) Multiome | 311 | |
| chr14:76,987,872–76,988,397 | 175.3 kb | Distal (>10kb) Multiome | 38 | |
| chr14:77,024,027–77,024,710 | 211.5 kb | Distal (>10kb) Multiome | 368 | |
| chr14:77,025,547–77,029,182 | 215.9 kb | Distal (>10kb) Multiome | 996 | |
| chr14:77,032,573–77,034,628 | 221.2 kb | Distal (>10kb) Multiome | 917 | |
| chr14:77,040,063–77,040,913 | 227.6 kb | Distal (>10kb) Multiome | 765 | |
| chr14:77,085,220–77,085,934 | 272.8 kb | Distal (>10kb) Multiome | 132 | |
| chr14:77,088,297–77,088,792 | 275.6 kb | Distal (>10kb) Multiome | 234 | |
| chr14:77,097,312–77,099,236 | 285.2 kb | Distal (>10kb) Multiome | 948 |
Genomic view of the ANGEL1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.