Involved in anaphase-promoting complex-dependent catabolic process; protein polyubiquitination; and regulation of mitotic cell cycle spindle assembly checkpoint. Part of anaphase-promoting complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ANAPC15. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ANAPC15 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ANAPC15, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:71,928,161–71,929,328 | 183.9 kb | Distal (>10kb) Multiome | 869 | |
| chr11:72,040,697–72,041,585 | 71.8 kb | Distal (>10kb) Multiome | 586 | |
| chr11:72,080,144–72,081,188 | 32.1 kb | Distal (>10kb) Multiome | 789 | |
| chr11:72,088,078–72,088,746 | 24.5 kb | Distal (>10kb) Multiome | 50 | |
| chr11:72,102,846–72,104,062 | 9.4 kb | Proximal (<10kb) Multiome | 870 | |
| chr11:72,111,979–72,113,129 | 211 bp | At TSS Multiome | 901 | |
| chr11:72,117,601–72,117,937 | 4.8 kb | Proximal (<10kb) | 10 | |
| chr11:72,222,505–72,225,138 | 110.6 kb | Distal (>10kb) Multiome | 815 | |
| chr11:72,237,525–72,239,038 | 125.5 kb | Distal (>10kb) Multiome | 427 | |
| chr11:72,239,350–72,240,441 | 127.1 kb | Distal (>10kb) Multiome | 349 | |
| chr11:72,243,706–72,244,831 | 131.5 kb | Distal (>10kb) Multiome | 234 |
Genomic view of the ANAPC15 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.