This gene encodes one of four critical components of the glycine cleavage system. Mutations in this gene have been associated with glycine encephalopathy. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
Transcription factors with Perturb-seq knockdown data for AMT. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = AMT upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of AMT, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:49,132,603–49,133,965 | 288.8 kb | Distal (>10kb) Multiome | 652 | |
| chr3:49,166,057–49,166,586 | 256.2 kb | Distal (>10kb) Multiome HiCAR | 622 | |
| chr3:49,170,896–49,171,950 | 251.1 kb | Distal (>10kb) Multiome | 781 | |
| chr3:49,276,912–49,277,398 | 145.4 kb | Distal (>10kb) Multiome | 291 | |
| chr3:49,339,607–49,340,853 | 82.3 kb | Distal (>10kb) Multiome HiCAR | 1044 | |
| chr3:49,357,868–49,359,083 | 64.0 kb | Distal (>10kb) Multiome | 908 | |
| chr3:49,411,409–49,412,844 | 10.3 kb | Distal (>10kb) Multiome | 899 | |
| chr3:49,422,179–49,422,905 | 48 bp | At TSS Multiome | 453 | |
| chr3:49,428,857–49,429,869 | 7.0 kb | Proximal (<10kb) Multiome | 712 | |
| chr3:49,461,484–49,462,134 | 39.3 kb | Distal (>10kb) Multiome | 207 | |
| chr3:49,468,926–49,470,930 | 47.7 kb | Distal (>10kb) Multiome | 919 | |
| chr3:49,539,369–49,540,584 | 117.5 kb | Distal (>10kb) Multiome | 628 | |
| chr3:49,553,618–49,555,244 | 132.0 kb | Distal (>10kb) Multiome | 710 | |
| chr3:49,718,116–49,720,106 | 297.1 kb | Distal (>10kb) Multiome | 450 |
Genomic view of the AMT locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.