Predicted to enable ATP binding activity; protein serine kinase activity; and protein serine/threonine kinase activity. Involved in several processes, including epicardium morphogenesis; heart development; and negative regulation of Wnt signaling pathway involved in heart development. Acts upstream of or within regulation of gene expression. Located in basolateral plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ALPK2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ALPK2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ALPK2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr18:58,424,566–58,425,218 | 154.2 kb | Distal (>10kb) Multiome | 69 | |
| chr18:58,556,324–58,556,895 | 22.7 kb | Distal (>10kb) Multiome | 131 | |
| chr18:58,628,791–58,629,668 | 50.0 kb | Distal (>10kb) Multiome | 156 | |
| chr18:58,670,687–58,672,355 | 92.2 kb | Distal (>10kb) Multiome | 783 | |
| chr18:58,694,693–58,695,388 | 115.9 kb | Distal (>10kb) Multiome | 196 | |
| chr18:58,768,204–58,768,929 | 189.4 kb | Distal (>10kb) Multiome | 427 | |
| chr18:58,829,548–58,830,499 | 250.8 kb | Distal (>10kb) Multiome | 168 | |
| chr18:58,846,800–58,849,106 | 268.7 kb | Distal (>10kb) Multiome | 416 | |
| chr18:58,863,566–58,864,932 | 285.1 kb | Distal (>10kb) Multiome | 286 | |
| chr18:58,867,169–58,867,750 | 288.3 kb | Distal (>10kb) Multiome | 136 |
Genomic view of the ALPK2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.