Transcription factors with Perturb-seq knockdown data for ALOX12P2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ALOX12P2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ALOX12P2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:6,556,250–6,556,832 | 297.4 kb | Distal (>10kb) Multiome | 166 | |
| chr17:6,640,233–6,641,593 | 213.0 kb | Distal (>10kb) Multiome | 878 | |
| chr17:6,650,954–6,652,333 | 202.3 kb | Distal (>10kb) Multiome HiCAR | 949 | |
| chr17:6,713,294–6,714,088 | 140.3 kb | Distal (>10kb) Multiome | 535 | |
| chr17:6,831,647–6,832,107 | 22.1 kb | Distal (>10kb) Multiome | 202 | |
| chr17:6,995,886–6,996,299 | 142.0 kb | Distal (>10kb) Multiome | 124 | |
| chr17:7,012,245–7,012,890 | 158.6 kb | Distal (>10kb) Multiome HiCAR | 804 | |
| chr17:7,014,335–7,015,213 | 160.9 kb | Distal (>10kb) Multiome HiCAR | 842 | |
| chr17:7,021,831–7,024,265 | 169.9 kb | Distal (>10kb) Multiome | 614 | |
| chr17:7,035,527–7,036,637 | 182.0 kb | Distal (>10kb) Multiome | 791 | |
| chr17:7,132,532–7,133,109 | 278.9 kb | Distal (>10kb) Multiome | 312 |
Genomic view of the ALOX12P2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.