Enables tRNA (uridine) methyltransferase activity; tRNA binding activity; and zinc ion binding activity. Involved in DNA damage response; tRNA methylation; and tRNA wobble uridine modification. Located in cytosol and nucleoplasm. Implicated in autosomal recessive intellectual developmental disorder 71. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ALKBH8. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ALKBH8 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ALKBH8, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:107,272,015–107,273,250 | 293.1 kb | Distal (>10kb) Multiome | 172 | |
| chr11:107,293,778–107,294,384 | 271.5 kb | Distal (>10kb) Multiome | 141 | |
| chr11:107,396,653–107,398,090 | 168.3 kb | Distal (>10kb) Multiome | 156 | |
| chr11:107,457,301–107,458,292 | 107.8 kb | Distal (>10kb) Multiome | 636 | |
| chr11:107,565,178–107,566,246 | 68 bp | At TSS Multiome | 741 | |
| chr11:107,569,743–107,570,490 | 4.0 kb | Proximal (<10kb) | 83 | |
| chr11:107,589,994–107,592,189 | 25.6 kb | Distal (>10kb) Multiome | 484 | |
| chr11:107,707,583–107,708,604 | 142.4 kb | Distal (>10kb) Multiome HiCAR | 189 | |
| chr11:107,833,401–107,834,470 | 268.3 kb | Distal (>10kb) Multiome | 123 | |
| chr11:107,857,895–107,860,083 | 293.2 kb | Distal (>10kb) Multiome | 916 |
Genomic view of the ALKBH8 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.